PRASUGREL DIKETONE
1-cyclopropyl-2-(2-fluorophenyl)ethane-1,2-dione
CAS: 1391054-37-7
Molecular Formula: C11H9FO2
PRASUGREL DIKETONE - Names and Identifiers
| Name | 1-cyclopropyl-2-(2-fluorophenyl)ethane-1,2-dione |
| Synonyms | Prasugrel dione Prasugrel diketone PRASUGREL DIKETONE Prasugrel IMpurity 4 Prasugrel Impurity G Prasugrel Diketo Impurity 1-cyclopropyl-2-(2-fluorophenyl)-1,2-ethanedione 1-cyclopropyl-2-(2-fluorophenyl)ethane-1,2-dione 1-cyclopropyl-2-(2-fluorophenyl) ethane-1,2-dione |
| CAS | 1391054-37-7 |
| InChI | InChI=1S/C11H9FO2/c12-9-4-2-1-3-8(9)11(14)10(13)7-5-6-7/h1-4,7H,5-6H2 |
PRASUGREL DIKETONE - Physico-chemical Properties
| Molecular Formula | C11H9FO2 |
| Molar Mass | 192.19 |
| Storage Condition | Room Temprature |
PRASUGREL DIKETONE - Reference Information
| Overview | 1-cyclopropyl-2-(2-fluorophenyl)-1, 2-ethandione, that is, prasugrel dione hydrochloride. Prasugrel hydrochloride is used as a platelet aggregation inhibitor to prevent and treat thrombosis. Prolonged exposure to air and water will cause certain degradation. According to the degradation pathway reported in the patent literature, prasugrel hydrochloride is Peroxide mediates the formation of N-oxide, and the N-oxide diastereomer is unstable in solution and will quickly degrade to acylated TTPO and prasiridone. Therefore, the quantitative synthesis of prasugrel dione hydrochloride is of great significance for the quality research of prasugrel hydrochloride and the detection of degradation impurities. |
| Preparation | A method for quantitative synthesis of prasugrel hydrochloride to degrade impurity diketones, namely 1-cyclopropyl-2-(2-fluorophenyl) ethanone, as the starting material, select the appropriate oxidant, the carbon atom adjacent to the ketone carbonyl group of 1-cyclopropyl-2-(2-fluorophenyl) ethanone is oxidized in the reaction solvent, and the one-step reaction is carried out to obtain the degradation of impurity diketone by prasugrel hydrochloride represented by formula I, namely 1-cyclopropyl-2-(2-fluorophenyl)-1, 2-ethandione (prasugrel dione), |
Last Update：2024-04-09 19:05:10
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